CRISPR genome editing
Behind the breakthrough: How Integrated DNA Technologies and Aldevron enabled the world’s first personalized CRISPR therapy
The world’s first personalized CRISPR therapy was delivered to a newborn in just six months and was made possible with the contribution of coordinated expertise of IDT and Aldevron, setting a new standard for precision medicine. IDT synthesized the therapeutic-grade guide RNA used in the CRISPR therapy and led a comprehensive off-target safety analysis across over 300 genomic sites, ensuring precision and safety at record speed. Aldevron manufactured the custom mRNA encoding the base editor and completed full drug product formulation, packaging, and quality control. Danaher—IGI Beacon for CRISPR Cures initiative, a collaboration between Innovative Genomic Institute (IGI) and Danaher Corporation, aims to create a scalable framework for delivering N-of-1 gene-editing therapies for rare genetic diseases.
- Behind the breakthrough: How Integrated DNA Technologies and Aldevron enabled the world’s first personalized CRISPR therapy
- CRISPR knock-out: Tips and tricks
- CRISPR-Cas nucleases: Understanding PAM requirements and Cas diversification strategies
- Navigating the regulatory landscape: A business perspective on cell and gene therapy approvals
- Successful CRISPR genome editing in hard-to-transfect cells (i.e., Jurkat cells)
- Tackling sickle cell disease with precise and efficient gene editing
- How to use CRISPR-Cas9 technology to generate mice models for research
- Importance of the PAM sequences in CRISPR-Cas9 gene editing
- HDR and Cas9 nickase design: What you should know
- CRISPR-Cas9: What are the pros and cons?
- Primer design and other tools you should know about
- Single base editing
- Customizing CAR-T cells using the CRISPR-Cas9 system
- CRISPR knock-in: Tips and tricks
- CRISPRa and CRISPRi: Similarities and differences you should know about
- The CRISPR Basics Handbook: An IDT publication to help you learn CRISPR
- Genome editing tip: A CRISPR RNA annealing step can increase editing efficiency
- CRISPR GUARD: A short gRNA-based system that facilitates precise genome edits
- Alt-R™ HDR Donor Blocks can enable long DNA knock-ins while decreasing undesired edits
- Improving efficiency of homology-directed repair (HDR)
- CRISPECTOR, a statistical CRISPR genome editing analysis software for research
- A.s. Cas12a Ultra, a highly effective CRISPR genome editing enzyme
- A fusion gene identification strategy using CRISPR-Cas9 and long read nanopore sequencing
- Genome Oligopaint: Painting a clearer picture with oPools™ Oligo Pools
- Analyze your CRISPR genome edits with IDT's cloud-based software
- CRISPR-based depletion of unwanted sequences improves targeted next generation sequencing
- Applications and benefits of CRISPR functional genomics screens using arrayed guide RNA libraries
- SHERLOCK, PAC-MAN, and more: How CRISPR-Cas13 enzymes may be useful in the COVID-19 pandemic and beyond
- Stability of CRISPR reagents under different freezing, storage, and thawing conditions
- Consider ribonucleoprotein (RNP) instead of CRISPR plasmids!
